What is the 2'-Deoxyguanosine monohydrate?

2'-Deoxyguanosine monohydrate is white crystalline powder, while it's Molecular Formula is C10H13N5O4. white crystalline powder 2'-Deoxyguanosine (Deoxyguanosine; dG) is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. It is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

What is the CAS number for 2'-Deoxyguanosine monohydrate?

The CAS number of 2'-Deoxyguanosine monohydrate is 961-07-9.

What is the 2'-Deoxyguanosine monohydrate?

2'-Deoxyguanosine monohydrate is white crystalline powder, while it's Molecular Formula is C10H13N5O4. white crystalline powder 2'-Deoxyguanosine (Deoxyguanosine; dG) is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. It is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

What is the CAS number for 2'-Deoxyguanosine monohydrate?

The CAS number of 2'-Deoxyguanosine monohydrate is 961-07-9.

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961-07-9

Product Name：2'-Deoxyguanosine monohydrate
Molecular Formula：C₁₀H₁₃N₅O₄
Purity：99%
Molecular Weight：267.244

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Product Details;

CasNo： 961-07-9

Molecular Formula： C₁₀H₁₃N₅O₄

Appearance： white crystalline powder

Factory of Top Purity 99% 149510-44-1

Molecular Formula:C10H13N5O4
Molecular Weight:267.244
Appearance/Colour:white crystalline powder
Melting Point:300 °C
Refractive Index:-42 ° (C=0.2, 1mol/L NaOH)
Boiling Point:725.475 °C at 760 mmHg
PKA:9?+-.0.20(Predicted)
Flash Point:392.553 °C
PSA：148.51000
Density:2.085 g/cm³
LogP:-1.14060

961-07-9 Relevant articles

Highly sequence selective photoreaction of 5-bromouracil-containing deoxyhexanucleotides

Sugiyama, Hiroshi,Tsutsumi, Yasushi,Saito, Isao

, p. 6720 - 6721 (1990)

Oxidative conversion of N-dimethylformamidine nucleosides to N-cyano nucleosides

Mullah,Mullah, Bashar,Andrus,Andrus, Alex,Zhao,Zhao, Hong,Jones,Jones, Roger A.

, p. 4373 - 4376 (1995)

Reaction of the N-dimethylformamidine (d...

Chemical composition and toxicity of Taiwanese betel quid extract

Wang,Su,Lii

, p. 135 - 144 (1999)

In this genotoxic study, the Ames Salmon...

Independent Generation and Time-Resolved Detection of 2′-Deoxyguanosin-N2-yl Radicals

Dai, Xiaojuan,Greenberg, Marc M.,Su, Hongmei,Zheng, Liwei

, (2020)

Guanine radicals are important reactive ...

Thermodynamic Reaction Control of Nucleoside Phosphorolysis

Kaspar, Felix,Giessmann, Robert T.,Neubauer, Peter,Wagner, Anke,Gimpel, Matthias

supporting information, p. 867 - 876 (2020/01/24)

Nucleoside analogs represent a class of ...

Independent Generation and Reactivity of 2′-Deoxyguanosin- N1-yl Radical

Zheng, Liwei,Greenberg, Marc M.

, p. 8665 - 8672 (2020/07/03)

2′-Deoxyguanosin-N1-yl radical (dG(N1-H)...

Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: A backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography

Conlon, Patrick F.,Eguaogie, Olga,Wilson, Jordan J.,Sweet, Jamie S. T.,Steinhoegl, Julian,Englert, Klaudia,Hancox, Oliver G. A.,Law, Christopher J.,Allman, Sarah A.,Tucker, James H. R.,Hall, James P.,Vyle, Joseph S.

, p. 10948 - 10957 (2019/12/23)

Oligodeoxynucleotides incorporating inte...

961-07-9 Process route

5'-d(AGTAT[5-ethynyl-U]GACCTA)-3': 5'-d(AGTAT[5-ethynyl-U]GACCTA)-3'

: 959326-89-7
2'-deoxycytidine

: 961-07-9
2'-Deoxyguanosine

: 61135-33-9
2'-deoxy-5-ethynyluridine

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 958-09-8,7005-15-4
2'-deoxy-D-adenosine

Conditions

Conditions	Yield
With tris hydrochloride; alkaline phosphatase; snake venom phosphodiesterase; at 37 ℃; pH=8.3; Enzymatic reaction;

calf thymus DNA, γ-irradiated: calf thymus DNA, γ-irradiated

: 31077-24-4,62471-63-0
8-oxo-7,8-dihydro-2'-deoxyguanosine

: 105929-27-9
(5'S)-5',8-cyclo-2'-deoxyguanosine

: 961-07-9
2'-Deoxyguanosine

: 88847-89-6
7,8-dihydro-8-oxo-2'-deoxyguanosine

: 117182-88-4
(5'S)-5',8-cyclo-2'-deoxyadenosine

: (5'R)-5',8-cyclo-2'-deoxyadenosine

: (5'R)-5',8-cyclo-2'-deoxyguanosine

: 951-77-9
2'-Deoxycytidine

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 958-09-8,7005-15-4
2'-deoxy-D-adenosine

Conditions

Conditions	Yield
calf thymus DNA, γ-irradiated; With DNase II; Penicillium citrium nuclease P₁; phosphodiesterase II; 9-erythro-(2-hydroxy-3-n-nonyl)adenine hydrochloride; at 37 ℃; for 2h; pH=6; aq. buffer; Enzymatic reaction; With phosphodiesterase I from Crotalus adamentus venom; alkaline phosphatase; at 37 ℃; for 2h; pH=8; aq. buffer; Enzymatic reaction; With DNase II; Penicillium citrium nuclease P₁; phosphodiesterase II; at 37 ℃; for 2h; pH=6; optical yield given as %de; aq. buffer; Enzymatic reaction;

Yield

calf thymus DNA, γ-irradiated; With DNase II; Penicillium citrium nuclease P₁; phosphodiesterase II; 9-erythro-(2-hydroxy-3-n-nonyl)adenine hydrochloride; at 37 ℃; for 2h; pH=6; aq. buffer; Enzymatic reaction;

With phosphodiesterase I from Crotalus adamentus venom; alkaline phosphatase; at 37 ℃; for 2h; pH=8; aq. buffer; Enzymatic reaction;

With DNase II; Penicillium citrium nuclease P₁; phosphodiesterase II; at 37 ℃; for 2h; pH=6; optical yield given as %de; aq. buffer; Enzymatic reaction;

961-07-9 Upstream products

17039-17-7
2-deoxy–α-D-ribose 1-phosphate
73-40-5
guanine
951-77-9
2'-Deoxycytidine
471-29-4
1-methylguanidine

961-07-9 Downstream products

902-04-5
2'-deoxyguanosine 5'-monophosphate
29049-22-7
2'-deoxyxanthosine
958-09-8
2'-deoxy-D-adenosine
79971-08-7
3',5'-O-dibutyryl 2'-deoxyguanosine

Product Classification

Contact us

961-07-9

Product Details;

Factory of Top Purity 99% 149510-44-1

961-07-9 Relevant articles

Highly sequence selective photoreaction of 5-bromouracil-containing deoxyhexanucleotides

Sugiyama, Hiroshi,Tsutsumi, Yasushi,Saito, Isao

, p. 6720 - 6721 (1990)

Oxidative conversion of N-dimethylformamidine nucleosides to N-cyano nucleosides

Mullah,Mullah, Bashar,Andrus,Andrus, Alex,Zhao,Zhao, Hong,Jones,Jones, Roger A.

, p. 4373 - 4376 (1995)

Chemical composition and toxicity of Taiwanese betel quid extract

Wang,Su,Lii

, p. 135 - 144 (1999)

Independent Generation and Time-Resolved Detection of 2′-Deoxyguanosin-N2-yl Radicals

Dai, Xiaojuan,Greenberg, Marc M.,Su, Hongmei,Zheng, Liwei

, (2020)

Thermodynamic Reaction Control of Nucleoside Phosphorolysis

Kaspar, Felix,Giessmann, Robert T.,Neubauer, Peter,Wagner, Anke,Gimpel, Matthias

supporting information, p. 867 - 876 (2020/01/24)

Independent Generation and Reactivity of 2′-Deoxyguanosin- N1-yl Radical

Zheng, Liwei,Greenberg, Marc M.

, p. 8665 - 8672 (2020/07/03)

Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: A backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography

Conlon, Patrick F.,Eguaogie, Olga,Wilson, Jordan J.,Sweet, Jamie S. T.,Steinhoegl, Julian,Englert, Klaudia,Hancox, Oliver G. A.,Law, Christopher J.,Allman, Sarah A.,Tucker, James H. R.,Hall, James P.,Vyle, Joseph S.

, p. 10948 - 10957 (2019/12/23)

961-07-9 Process route

961-07-9 Upstream products

961-07-9 Downstream products

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