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13860-38-3
- Product Name：1-methylpseudouridine
- Molecular Formula：C10H14 N2 O6
- Purity：99%
- Molecular Weight：258.231
Product Details;
CasNo： 13860-38-3
Molecular Formula： C10H14 N2 O6
Description N1-Methylpseudouridine is a modified nucleoside used for enhancing mRNA translation. Incorporation of N1-Methylpseudouridine into mRNA turns off the immune/eIF2α phosphorylation-dependent inhibition of translation, and increases ribosome pausing and density on the mRNA, thus dramatically facilitating the translation process. N1-Methylpseudouridine outperforms several other modified nucleosides (e.g. 5-Methylcytidine) and corresponding combinations in terms of translation capacity. Definition ChEBI: 1-methylpseudouridine is a methylpseudouridine in which the methyl group is located at position N-1 on the uracil ring. Application 1-Methylpseudouridine is a substitute for uridine in modified mRNA. This substitution has shown to increase transfection by reducing immuogenicity. The 1-methylpseudouridine substituted mRNA increases protein expression due to low immune stimulation as it evades detection by the edosomal Toll-like receptor (TLR3). InChI:InChI=1/C10H14N2O6/c1-12-2-4(9(16)11-10(12)17)8-7(15)6(14)5(3-13)18-8/h2,5-8,13-15H,3H2,1H3,(H,11,16,17)
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This invention provides expressible poly...
A series of 3-substituted uridine and ps...
A convenient synthesis of N1-methyl-2'-d...
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1-methyl-5'-O-(tert-butyldiphenylsilyl)-2',3'-O-(isopropylidene)pseudouridine N1-methylpseudouridine N1-methyl-2',3',5'-tri-O-acetyl-ψ-uridine N1-methylpseudouridine
pseudouridine
methyl iodide
N1-methyl-2',3',5'-tri-O-acetyl-ψ-uridine
5-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrimidine-2,4-(1H,3H)-dione
1-methyl-2'-O-tosylpseudouridine
1-methyl-3'-O-tosylpseudouridine
Pseudothymidine
N1-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-ψ-uridine
Reasoble Price Trader 1-methylpseudouridine 13860-38-3 In Medicine
1-methylpseudouridine(Cas 13860-38-3) Usage
13860-38-3 Relevant articles
Nucleosides. CVI. Synthesis of 1 N methyl 5 (β D ribofuranosyl)uracil (1 N methyl psi uridine) and its identity with a metabolite elaborated by Streptomyces platensis var. clarensis
Reichman,Hirota,Chu,et al.
, p. 129 - 131 (1977)
SYNTHESIS AND STRUCTURE OF HIGH POTENCY RNA THERAPEUTICS
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, (2019/01/15)
Synthesis and solution conformation studies of 3-substituted uridine and pseudouridine derivatives
Chang, Yu-Cheng,Herath, Jayatilake,Wang, Tony H.-H.,Chow, Christine S.
, p. 2676 - 2686 (2008/09/21)
A practical synthesis of N1-methyl-2'-deoxy-ψ-uridine (ψ-thymidine) and its incorporation into G-rich triple helix forming oligonucleotides
Bhattacharya,Devivar,Revankar
, p. 1269 - 1287 (2007/10/02)
Nucleosides. 120. Syntheses of 2'-deoxy-ψ-isocytidine and 2'-deoxy-1-methyl-ψ-uridine from ψ-uridine
Matsuda,Chu,Reichman,et al.
, p. 3603 - 3609 (2007/10/02)
13860-38-3 Process route
Conditions
Yield
90%
Conditions
Yield
90%
13860-38-3 Upstream products
13860-38-3 Downstream products
