What is the 4-THIOURIDINE?

4-THIOURIDINE is Light yellow crystalline, while it's Molecular Formula is C9H12N2O5S. Light yellow crystalline 4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.

What is the CAS number for 4-THIOURIDINE?

The CAS number of 4-THIOURIDINE is 13957-31-8.

What is 4-THIOURIDINE (13957-31-8) used for?

4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.InChI:InChI=1/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)

What is the 4-THIOURIDINE?

4-THIOURIDINE is Light yellow crystalline, while it's Molecular Formula is C9H12N2O5S. Light yellow crystalline 4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.

What is the CAS number for 4-THIOURIDINE?

The CAS number of 4-THIOURIDINE is 13957-31-8.

What is 4-THIOURIDINE (13957-31-8) used for?

4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.InChI:InChI=1/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)

Product Classification

Contact us

Tel：021-6710 8196

Phone：191 2194 8821

Website：https://www.xhmedi.com

Email： sales@xhmedic.com

Address：Room 306, Building A, 1888 Wangyuan Road, Fengxian District, Shanghai，China





13957-31-8

Product Name：4-thiouridine
Molecular Formula：C₉H₁₂N₂O₅S
Purity：99%
Molecular Weight：260.271

Inquiry

Product Details;

CasNo： 13957-31-8

Molecular Formula： C₉H₁₂N₂O₅S

Appearance： Light yellow crystalline

High Quality Factory Sells 4-thiouridine 13957-31-8 In Bulk Supply

Molecular Formula:C9H12N2O5S
Molecular Weight:260.271
Appearance/Colour:Light yellow crystalline
Melting Point:139-140℃ (ethanol )
Refractive Index:1.732
PKA:4.75±0.20(Predicted)
PSA：139.80000
Density:1.72 g/cm³
LogP:-1.48260

4-THIOURIDINE(Cas 13957-31-8) Usage

Description	4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.
Uses	Nucleotide analogue, essential for cell growth in certain bacterial species. This compound is also able to chelate with certain metal ions, and in tRNA it can act as a built-in antiphotomutagenic agent that protects Escherichia coli cells against mutagenesis.
Definition	ChEBI: A thiouridine in which the oxygen replaced by sulfur is that at C-4.
General Description	4-Thiouridine is a photoreactive uridine analog.
Biochem/physiol Actions	4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.

InChI:InChI=1/C9H12N2O5S/c12-3-4-6(13)7(14)8(16-4)11-2-1-5(17)10-9(11)15/h1-2,4,6-8,12-14H,3H2,(H,10,15,17)

13957-31-8 Relevant articles

Isolation and characterization of pyrimidine sulfenic acid via scission of the sulfur-sulfur bond in the methyl analog of bis(4-thiouridine) disulfide.

Pal,Uziel,Doherty,Cohn

, p. 3634 - 3638 (1969)

Chemical Conversion of Uridine into 4-Thiouridine via the 4-(1,2,4-Triazol-1-yl)pyrimidin-2(1H)-one Intermediate

Sung, Wing L.

, p. 522 - 523 (1982)

In an aqueous solution of sodium hydrosu...

Some synthetic analogues of uridine diphosphate glucose.

Kochetkov,Budowsky,Shibaev,Yeliseeva,Grachev,Demushkin

, p. 1207 - 1218 (1963)

Synthesis and Metabolic Fate of 4-Methylthiouridine in Bacterial tRNA

Borek, Christoph,Reichle, Valentin F.,Kellner, Stefanie

, p. 2768 - 2771 (2020)

Ribonucleic acid (RNA) is central to man...

Anti-hepatitis B virus compound as well as preparation method and application thereof

-

Paragraph 0033-0035, (2021/06/22)

The invention provides an anti-hepatitis...

SYNTHESIS AND STRUCTURE OF HIGH POTENCY RNA THERAPEUTICS

-

, (2019/01/15)

This invention provides expressible poly...

Systematic assignment of NMR spectra of 5-substituted-4-thiopyrimidine nucleosides

Zhang, Xiaohui,Wang, Jian,Xu, Yao-Zhong

, p. 523 - 529 (2013/09/02)

Unambiguous characterization of 5-substi...

13957-31-8 Process route

: 55003-25-3
4-thio-1-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-(3H)-pyrimidine-2,4-dione

: 13957-31-8
4-thiouridine

Conditions

Conditions	Yield
With ammonia; In methanol; for 12h;	90%
With sodium methylate;	89%
With ammonia; In methanol; at 20 ℃; for 4.5h;
With methanol; ammonia; at 20 ℃; for 16h;

: 58-96-8
uridine

: 13957-31-8
4-thiouridine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 97 percent / (Me₃Si)2NH 2: 54 percent / NaH / tetrahydrofuran 3: 54 percent / K₂CO₃ / aq. ethanol / 3 h / 25 °C 4: AcOH / tetrahydrofuran; H₂O 5: 95 percent / conc. NH₄OH / 0.5 h / 25 °C With ammonium hydroxide; sodium hydride; potassium carbonate; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; ethanol; water;
Multi-step reaction with 3 steps 1: pyridine 2: P₂S₅ 3: methanol. sodium methylate With pyridine; tetraphosphorus decasulfide; sodium methylate;
Multi-step reaction with 3 steps 1: pyridine / 3 h / 60 °C 2: Lawessons reagent / benzene / 24 h / Reflux 3: ammonia / methanol / 12 h With Lawessons reagent; pyridine; ammonia; In methanol; benzene;
Multi-step reaction with 3 steps 1: pyridine / 5 h / 0 °C 2: tetraphosphorus decasulfide / 1,4-dioxane / 1.5 h / 106 °C 3: ammonia / methanol / 4.5 h / 20 °C With pyridine; tetraphosphorus decasulfide; ammonia; In 1,4-dioxane; methanol;
Multi-step reaction with 3 steps 1: iodine / 0.75 h / 20 °C 2: tetraphosphorus decasulfide; pyridine / 4 h / Reflux 3: ammonium hydroxide / water / 2 h / Reflux With pyridine; ammonium hydroxide; tetraphosphorus decasulfide; iodine; In water;

13957-31-8 Upstream products

15049-50-0
1-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-4-thiouracil
53337-88-5
2-methoxy-1-β-D-ribofuranosyl-pyrimidine-4-one
136055-18-0
S-(2-cyanoethyl)-4-thiouridine
59495-20-4
4-ethoxy-1-(β-D-ribofuranosyl)-2(1H)-pyrimidinone

13957-31-8 Downstream products

3258-02-4
1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(hydroxylamino)pyrimidin-2(1H)-one
18427-02-6
Di-(4-deoxy-4-uridinyl)-disulfid
144303-79-7
1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-methyldisulfanyl-1H-pyrimidin-2-one
74972-87-5
S-(N-(4-anilino-1-naphthyl)carbamylmethyl)-4-thiouridine

Product Classification

Contact us

13957-31-8

Product Details;

High Quality Factory Sells 4-thiouridine 13957-31-8 In Bulk Supply

4-THIOURIDINE(Cas 13957-31-8) Usage

13957-31-8 Relevant articles

Isolation and characterization of pyrimidine sulfenic acid via scission of the sulfur-sulfur bond in the methyl analog of bis(4-thiouridine) disulfide.

Pal,Uziel,Doherty,Cohn

, p. 3634 - 3638 (1969)

Chemical Conversion of Uridine into 4-Thiouridine via the 4-(1,2,4-Triazol-1-yl)pyrimidin-2(1H)-one Intermediate

Sung, Wing L.

, p. 522 - 523 (1982)

Some synthetic analogues of uridine diphosphate glucose.

Kochetkov,Budowsky,Shibaev,Yeliseeva,Grachev,Demushkin

, p. 1207 - 1218 (1963)

Synthesis and Metabolic Fate of 4-Methylthiouridine in Bacterial tRNA

Borek, Christoph,Reichle, Valentin F.,Kellner, Stefanie

, p. 2768 - 2771 (2020)

Anti-hepatitis B virus compound as well as preparation method and application thereof

-

Paragraph 0033-0035, (2021/06/22)

SYNTHESIS AND STRUCTURE OF HIGH POTENCY RNA THERAPEUTICS

-

, (2019/01/15)

Systematic assignment of NMR spectra of 5-substituted-4-thiopyrimidine nucleosides

Zhang, Xiaohui,Wang, Jian,Xu, Yao-Zhong

, p. 523 - 529 (2013/09/02)

13957-31-8 Process route

13957-31-8 Upstream products

13957-31-8 Downstream products

Contact us

Products

Site Map

Contact us