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367511-37-3

  • Product Name：1-((2R,3R,4R,5R)-4-((tert-Butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
  • Molecular Formula：
  • Purity：99%
  • Molecular Weight：486.756
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Product Details;

CasNo： 367511-37-3

High Purity Fast Delivery 1-((2R,3R,4R,5R)-4-((tert-Butyldimethylsilyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 367511-37-3 In Stock

  • Molecular Formula:C22H42N2O6Si2
  • Molecular Weight:486.756

367511-37-3 Relevant articles

Synthesis of a novel cyclopropyl phosphonate nucleotide as a phosphate mimic

Altenhofer, Erich F.,Fowler-Watters, Matthew,Joyce, Leo A.,Kumar, Pankaj,Lawler, Michael J.,Li, Zhen,Pei, Tao

supporting information, p. 6808 - 6811 (2021/07/13)

The inherentin vivoinstability of oligon...

S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS

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Paragraph 0068; 0474, (2021/06/22)

Various embodiments provide STOPS? polym...

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

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Page/Page column 623, (2016/06/15)

The present disclosure provides alternat...

ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF

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Page/Page column 631, (2016/06/28)

The present disclosure provides alternat...

367511-37-3 Process route

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

2'-O-methyluridine
2140-76-3

2'-O-methyluridine

C<sub>22</sub>H<sub>42</sub>N<sub>2</sub>O<sub>6</sub>Si<sub>2</sub>
367511-37-3

C22H42N2O6Si2

Conditions
Conditions Yield
With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
85%
With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
85%
With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
85%
With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
85%
With 1H-imidazole; In N,N-dimethyl-formamide;
With 1H-imidazole; In N,N-dimethyl-formamide; at 5 - 23 ℃; for 20h;
With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 15h; Inert atmosphere;
C<sub>22</sub>H<sub>42</sub>N<sub>2</sub>O<sub>6</sub>Si<sub>2</sub>
367511-37-3

C22H42N2O6Si2

2’-O-(tert-butyldimethylsilyl)-5’-O-(4,4’-dimethoxytrityl)uridin-3’-yl 5’-O-levulinoyl-2’-O-methyluridin-3’-yl N,N-diisopropylphosphoramidite

2’-O-(tert-butyldimethylsilyl)-5’-O-(4,4’-dimethoxytrityl)uridin-3’-yl 5’-O-levulinoyl-2’-O-methyluridin-3’-yl N,N-diisopropylphosphoramidite

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: trifluoroacetic acid / water; tetrahydrofuran
2: dicyclohexyl-carbodiimide; pyridine / 1,4-dioxane / 16 h / 20 °C
3: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 64 h / 20 °C
4: benzyl tetrazol-5-yl sulphide / acetonitrile / 16 h / 20 °C / Inert atmosphere
With pyridine; benzyl tetrazol-5-yl sulphide; triethylamine tris(hydrogen fluoride); dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;

367511-37-3 Upstream products

  • 18162-48-6
    18162-48-6

    tert-butyldimethylsilyl chloride

  • 2140-76-3
    2140-76-3

    2'-O-methyluridine

367511-37-3 Downstream products

  • 171268-84-1
    171268-84-1

    1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

  • 1428902-86-6
    1428902-86-6

    C24H43N5O5Si2

  • 1613530-40-7
    1613530-40-7

    C23H45N3O5Si2

  • 13048-95-8
    13048-95-8

    N4,2'-O-dimethylcytidine

CAS Index: 1 2 3 4 5 6 7 8 9

Chemical Name Index: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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