Product Classification
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17331-22-5
- Product Name：5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE
- Molecular Formula：C31H31 N5 O5
- Purity：99%
- Molecular Weight：553.618
Product Details;
CasNo： 17331-22-5
Molecular Formula： C31H31 N5 O5
Good Price Factory Sells High Purity 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE 17331-22-5
- Molecular Formula:C31H31 N5 O5
- Molecular Weight:553.618
- Melting Point:97-98 °C(Solv: chloroform (67-66-3); ligroine (8032-32-4))
- Boiling Point:785.1±70.0 °C(Predicted)
- PKA:13.75±0.60(Predicted)
- PSA：126.77000
- Density:1.35±0.1 g/cm3(Predicted)
- LogP:4.66400
17331-22-5 Relevant articles
Transient Protection: Efficient One-Flask Syntheses of Protected Deoxynucleosides
Ti, G. S.,Gaffney, B. L.,Jones, R. A.
, p. 1316 - 1319 (1982)
Application of the concept of transient ...
A Convenient Method for the Synthesis of N-Free 5′-O-(p,p′-Dimethoxytrityl)-2′-deoxyribonucleosides via the 5′-O-Selective Tritylation of the Parent Substances
Kataoka, Masanori,Hayakawa, Yoshihiro
, p. 6087 - 6089 (1999)
-
Characterization of high molecular weight impurities in synthetic phosphorothioate oligonucleotides
Kurata, Christine,Bradley, Kym,Gaus, Hans,Luu, Nhuy,Cedillo, Isaiah,Ravikumar, Vasulinga T.,Sooy, Kent Van,McArdle, James V.,Capaldi, Daniel C.
, p. 607 - 614 (2006)
Phosphorothioate oligonucleotides manufa...
MODIFIED NUCLEOTIDES FOR SYNTHESIS OF NUCLEIC ACIDS, A KIT CONTAINING SUCH NUCLEOTIDES AND THEIR USE FOR THE PRODUCTION OF SYNTHETIC NUCLEIC ACID SEQUENCES OR GENES
-
Paragraph 0118, (2020/08/05)
A modified nucleotide, intended for the ...
Conversion of adenine to 5-amino-4-pyrimidinylimidazole caused by acetyl capping during solid phase oligonucleotide synthesis
Rodriguez, Andrew A.,Cedillo, Isaiah,McPherson, Andrew K.
, p. 3468 - 3471 (2016/07/21)
The acetyl capping reaction used through...
Synthesis of disaccharide nucleosides by the O-glycosylation of natural nucleosides with thioglycoside donors
Aoki, Shin,Fukumoto, Taketo,Itoh, Taiki,Kurihara, Masayuki,Saito, Shigeto,Komabiki, Shin-Ya
, p. 740 - 751 (2015/06/02)
Disaccharide nucleosides constitute an i...
17331-22-5 Process route
-
-
40615-36-9
4,4'-dimethoxytrityl chloride
-
-
958-09-8,7005-15-4
2'-deoxy-D-adenosine
-
![5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine](/upload/2023/7\bba23811-0dbf-45c6-bd1a-5b28b375b40d.png)
-
17331-22-5
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine
| Conditions | Yield |
|---|---|
|
With
1H-imidazole; methanesulfonic acid; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
|
86% |
|
With
pyridine; dmap; triethylamine;
for 4h;
|
77% |
|
With
pyridine;
at 0 - 20 ℃;
|
68% |
|
With
pyridine; dmap; triethylamine;
at 13 ℃;
for 12h;
|
|
|
|
|
|
4,4'-dimethoxytrityl chloride; 2'-deoxy-D-adenosine;
With
pyridine; dmap; triethylamine;
at 20 ℃;
With
methanesulfonyl chloride; triethylamine;
at 20 ℃;
for 2h;
|
-
-
329781-61-5
2-azidomethyl-N-(9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide
-
-
17331-22-5
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxyadenosine
| Conditions | Yield |
|---|---|
|
With
diphenyl(methyl)phosphine;
In
1,4-dioxane; water;
at 20 ℃;
for 0.333333h;
|
90% |
17331-22-5 Upstream products
-
40615-36-9
4,4'-dimethoxytrityl chloride
-
958-09-8
2'-deoxy-D-adenosine
-
187674-19-7
(9-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-9H-purin-6-yl)-carbamic acid 2-(5-dimethylamino-naphthalene-1-sulfonyl)-ethyl ester
-
84780-16-5
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N6-phthaloyladenosine
17331-22-5 Downstream products
-
112677-85-7
Phosphoric acid diallyl ester (2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester
-
134817-00-8
Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(6-amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester methyl ester
-
89947-86-4
5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine
-
958-09-8
2'-deoxy-D-adenosine
