What is the 2'-O-Methylguanosine?

2'-O-Methylguanosine is White solid, while it's Molecular Formula is C11H15N5O5. White solid Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

What is the CAS number for 2'-O-Methylguanosine?

The CAS number of 2'-O-Methylguanosine is 2140-71-8.

What is 2'-O-Methylguanosine (2140-71-8) used for?

2''-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine (Item Nos. 16376 | 13956) as a substrate. Through its interaction with other modified nucleosides, 2''-O-methylguanosine is thought to stabilize the structure of the tRNA. 2''-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2''-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.

What is the 2'-O-Methylguanosine?

2'-O-Methylguanosine is White solid, while it's Molecular Formula is C11H15N5O5. White solid Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.

What is the CAS number for 2'-O-Methylguanosine?

The CAS number of 2'-O-Methylguanosine is 2140-71-8.

What is 2'-O-Methylguanosine (2140-71-8) used for?

2''-O-Methylguanosine is a modified nucleoside that is produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase, using S-adenosyl-L-methionine (Item Nos. 16376 | 13956) as a substrate. Through its interaction with other modified nucleosides, 2''-O-methylguanosine is thought to stabilize the structure of the tRNA. 2''-O-Methylguanosine can also be found in rRNA. Normal and modified nucleosides, including 2''-O-methylguanosine, have been shown to be secreted by a natural suppressor cell line and induce apoptosis in K562/Molt4 target cells.

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2140-71-8

Product Name：2'-O-Methylguanosine
Molecular Formula：C₁₁H₁₅N₅O₅
Purity：99%
Molecular Weight：297.27

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Product Details;

CasNo： 2140-71-8

Molecular Formula： C₁₁H₁₅N₅O₅

Appearance： White solid

Fast Delivery Pharmaceutical Grade 2'-O-Methylguanosine 2140-71-8 In Stock

Molecular Formula:C11H15N5O5
Molecular Weight:297.27
Appearance/Colour:White solid
Melting Point:227-231°C (dec.)
Boiling Point:711.724 °C at 760 mmHg
PKA:9?+-.0.20(Predicted)
Flash Point:384.237 °C
PSA：148.51000
Density:1.983 g/cm³
LogP:-1.45140

2140-71-8 Relevant articles

Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth—Generation by Prebiotic Methylations and Carbamoylations

Schneider, Christina,Becker, Sidney,Okamura, Hidenori,Crisp, Antony,Amatov, Tynchtyk,Stadlmeier, Michael,Carell, Thomas

supporting information, p. 5943 - 5946 (2018/04/30)

The RNA-world hypothesis assumes that li...

PROCESS FOR THE SYNTHESIS OF 2'-O-SUBSTITUTED PURINES

-

Page/Page column 8, (2008/12/07)

The present invention provides an improv...

An efficient process for synthesis of 2′-O-methyl and 3′-O-methyl guanosine from 2-aminoadenosine using diazomethane and the catalyst stannous chloride

Kore, Anilkumar,Parmar, Gaurang,Reddy, Srinu

, p. 307 - 314 (2007/10/03)

An improved strategy for the selective s...

MDPSCL2: a new protecting group for chemoselective synthesis of 2'-O-alkylated guanosines.

Chow, Suetying,Wen,Sanghvi, Yogesh S,Theodorakis, Emmanuel A

, p. 583 - 587 (2007/10/03)

An improved strategy for the synthesis o...

2140-71-8 Process route

: 17287-03-5
trimethylsulphonium hydroxide

: 118-00-3
G

: 10300-27-3
3’-O-methylguanosine

: 2140-71-8
2'-O-methylguanosine

: 73667-71-7
1,2'-Dimethylguanosine

: 2140-65-0
1-methylguanosine

Conditions

Conditions	Yield
In methanol; N,N-dimethyl-formamide; at 70 ℃; for 1h; Further byproducts given;	11 % Spectr. 4 % Spectr. 23 % Spectr. 53%
With copper acetylacetonate; In N,N-dimethyl-formamide; at 70 ℃; for 1h; Further byproducts given;	18% 17% 15% 16%
With copper acetylacetonate; In N,N-dimethyl-formamide; at 70 ℃; for 1h; Further byproducts given;	18% 15% 15% 17%

: 17287-03-5
trimethylsulphonium hydroxide

: 118-00-3
G

: 10300-27-3
3’-O-methylguanosine

: 2140-71-8
2'-O-methylguanosine

: 74466-66-3
1,3'-Dimethylguanosine

: 2140-65-0
1-methylguanosine

Conditions

Conditions	Yield
With copper acetylacetonate; In N,N-dimethyl-formamide; at 70 ℃; for 1h; Further byproducts given;	18% 17% 16% 12%

2140-71-8 Upstream products

80791-87-3
2-amino-2'-O-methyladenosine
17287-03-5
trimethylsulphonium hydroxide
118-00-3
G
188658-55-1
6-(tert-Butyl-diphenyl-silanyloxy)-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-2-ylamine

2140-71-8 Downstream products

183737-04-4
N₂-dimethylaminomethylene-2'-O-methylguanosine
444019-11-8
N²-(4-monomethoxytrityl)-2'-O-methylguanosine
215190-95-7
Pent-4-enoic acid (9-{(2R,3R,4R,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-amide
63264-29-9
N²-isobutyryl-2′-O-methylguanosine

Product Classification

Contact us

2140-71-8

Product Details;

Fast Delivery Pharmaceutical Grade 2'-O-Methylguanosine 2140-71-8 In Stock

2140-71-8 Relevant articles

Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth—Generation by Prebiotic Methylations and Carbamoylations

Schneider, Christina,Becker, Sidney,Okamura, Hidenori,Crisp, Antony,Amatov, Tynchtyk,Stadlmeier, Michael,Carell, Thomas

supporting information, p. 5943 - 5946 (2018/04/30)

PROCESS FOR THE SYNTHESIS OF 2'-O-SUBSTITUTED PURINES

-

Page/Page column 8, (2008/12/07)

An efficient process for synthesis of 2′-O-methyl and 3′-O-methyl guanosine from 2-aminoadenosine using diazomethane and the catalyst stannous chloride

Kore, Anilkumar,Parmar, Gaurang,Reddy, Srinu

, p. 307 - 314 (2007/10/03)

MDPSCL2: a new protecting group for chemoselective synthesis of 2'-O-alkylated guanosines.

Chow, Suetying,Wen,Sanghvi, Yogesh S,Theodorakis, Emmanuel A

, p. 583 - 587 (2007/10/03)

2140-71-8 Process route

2140-71-8 Upstream products

2140-71-8 Downstream products

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