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171268-84-1

  • Product Name：3'-O-TBDMS-2'-OME-U
  • Molecular Formula：
  • Purity：99%
  • Molecular Weight：372.494
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Product Details;

CasNo： 171268-84-1

Top Purity 3'-O-TBDMS-2'-OME-U 171268-84-1 Powder In Bulk supply

  • Molecular Formula:C16H28N2O6Si
  • Molecular Weight:372.494
  • Density:1.20±0.1 g/cm3(Predicted) 

171268-84-1 Relevant articles

Synthesis of a novel cyclopropyl phosphonate nucleotide as a phosphate mimic

Altenhofer, Erich F.,Fowler-Watters, Matthew,Joyce, Leo A.,Kumar, Pankaj,Lawler, Michael J.,Li, Zhen,Pei, Tao

, p. 6808 - 6811 (2021)

The inherentin vivoinstability of oligon...

Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′-(E)- and 5′-(Z)-Vinylphosphonate-Modified siRNA Conjugates

Parmar, Rubina Giare,Brown, Christopher R.,Matsuda, Shigeo,Willoughby, Jennifer L. S.,Theile, Christopher S.,Charissé, Klaus,Foster, Donald J.,Zlatev, Ivan,Jadhav, Vasant,Maier, Martin A.,Egli, Martin,Manoharan, Muthiah,Rajeev, Kallanthottathil G.

, p. 734 - 744 (2018)

(E)-Vinylphosphonate ((E)-VP), a metabol...

S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS

-

Paragraph 0068; 0475, (2021/06/22)

Various embodiments provide STOPS? polym...

5'-END DERIVATIVES

-

Paragraph 0600, (2014/01/07)

The present invention provides compounds...

171268-84-1 Process route

C<sub>22</sub>H<sub>42</sub>N<sub>2</sub>O<sub>6</sub>Si<sub>2</sub>
367511-37-3

C22H42N2O6Si2

1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
171268-84-1

1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Conditions
Conditions Yield
With trifluoroacetic acid; In tetrahydrofuran; water;
With trifluoroacetic acid; In dichloromethane; for 20h;
8.91 g
With water; trifluoroacetic acid; at 0 ℃; for 0.5h;
36.6 g
N<SUP>3</SUP>-benzyloxymethyl-2'-O-methyl-3'-O-tert-butyldimethylsilyluridine
1134031-93-8

N3-benzyloxymethyl-2'-O-methyl-3'-O-tert-butyldimethylsilyluridine

1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
171268-84-1

1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Conditions
Conditions Yield
With palladium 10% on activated carbon; hydrogen; In methanol;
100%

171268-84-1 Upstream products

  • 1134031-93-8
    1134031-93-8

    N3-benzyloxymethyl-2'-O-methyl-3'-O-tert-butyldimethylsilyluridine

  • 171268-85-2
    171268-85-2

    C37H46N2O8Si

  • 2140-76-3
    2140-76-3

    2'-O-methyluridine

  • 367511-37-3
    367511-37-3

    C22H42N2O6Si2

171268-84-1 Downstream products

  • 1134031-97-2
    1134031-97-2

    C42H50Cl4N2O16Si

  • 1134032-00-0
    1134032-00-0

    C42H50Cl4N2O16Si

  • 1134031-93-8
    1134031-93-8

    N3-benzyloxymethyl-2'-O-methyl-3'-O-tert-butyldimethylsilyluridine

CAS Index: 1 2 3 4 5 6 7 8 9

Chemical Name Index: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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