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199593-09-4

  • Product Name:2'-OMe-Ac-C Phosphoramidite
  • Molecular Formula:C42H52N5O9P
  • Purity:99%
  • Molecular Weight:801.877
Inquiry

Product Details;

CasNo: 199593-09-4

Molecular Formula: C42H52N5O9P

High Quality Wholesale Price 2'-OMe-Ac-C Phosphoramidite 199593-09-4 In Stock

  • Molecular Formula:C42H52N5O9P
  • Molecular Weight:801.877
  • Melting Point:102 - 104°C 
  • PKA:10.18±0.20(Predicted) 
  • PSA:169.22000 
  • LogP:6.87418 

199593-09-4 Relevant articles

Ultrafast cleavage and deprotection of oligonucleotides synthesis and use of C(Ac) derivatives

Reddy,Hanna, Naeem B.,Farooqui, Firdous

, p. 1589 - 1598 (2007/10/03)

We have investigated the use of alkylami...

199593-09-4 Process route

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine
124482-92-4,89992-70-1

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

N-(1-((2R,3R,4R,5R)-5-((bis(4-Methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide
199593-08-3

N-(1-((2R,3R,4R,5R)-5-((bis(4-Methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
199593-09-4,213020-84-9,213020-85-0

Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
65%
4,4'-dimethoxytrityl chloride
40615-36-9

4,4'-dimethoxytrityl chloride

Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
199593-09-4,213020-84-9,213020-85-0

Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-5-(4-acetylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-methoxy-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 70 percent / pyridine
2: 65 percent / iPr2NEt / tetrahydrofuran
With pyridine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

199593-09-4 Upstream products

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    N-(1-((2R,3R,4R,5R)-5-((bis(4-Methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

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    4,4'-dimethoxytrityl chloride

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    N4-acetyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine

199593-09-4 Downstream products

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    5'-O-dimethoxytritil-2'-O-methylcytidine-3'-O-(2-cianoethyl-N,N-diisopropylphosphoramidite)

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