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1219089-85-6

  • Product Name:Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-, 2'-(1,1-dioxido-4-thiomorpholinecarbothioate)
  • Molecular Formula:
  • Purity:99%
  • Molecular Weight:816.956
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Product Details;

CasNo: 1219089-85-6

Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-, 2'-(1,1-dioxido-4-thiomorpholinecarbothioate) is a synthetic compound that has been developed for use as a potent and selective inhibitor of the enzyme dipeptidyl peptidase IV (DPP-IV). DPP-IV is an enzyme that plays a role in the regulation of blood glucose levels by breaking down incretins, a group of hormones that stimulate insulin release from the pancreas. By inhibiting DPP-IV, Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-, 2'-(1,1-dioxido-4-thiomorpholinecarbothioate) can increase the levels of incretins in the blood, leading to improved glucose control in patients with type 2 diabetes. This compound is currently undergoing clinical trials for its safety and efficacy as a potential treatment for type 2 diabetes.

 

Low Price For Sale High Purity Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-, 2'-(1,1-dioxido-4-thiomorpholinecarbothioate) 1219089-85-6

  • Molecular Formula:C40H44N6O9S2
  • Molecular Weight:816.956

1219089-85-6 Relevant articles

PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS

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Page/Page column 43-44, (2010/04/23)

A nucleoside monomer that is protected b...

1219089-85-6 Process route

2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-N6-isobutyryl-riboadenosine
1219089-84-5

2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-N6-isobutyryl-riboadenosine

4,4'-dimethoxytrityl chloride
40615-36-9

4,4'-dimethoxytrityl chloride

C<sub>40</sub>H<sub>44</sub>N<sub>6</sub>O<sub>9</sub>S<sub>2</sub>
1219089-85-6

C40H44N6O9S2

Conditions
Conditions Yield
With 2,4,6-trimethyl-pyridine; In tetrahydrofuran; at 20 ℃;
 
C<sub>40</sub>H<sub>44</sub>N<sub>6</sub>O<sub>9</sub>S<sub>2</sub>
1219089-85-6

C40H44N6O9S2

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine
124482-92-4,89992-70-1

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-5'-O-(4,4'-dimethoxytrityl)-N6-isobutyryl-adenosine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite
1219089-86-7

2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-5'-O-(4,4'-dimethoxytrityl)-N6-isobutyryl-adenosine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite

Conditions
Conditions Yield
With 1-methyl-1H-imidazole; 2,4,6-trimethyl-pyridine; In tetrahydrofuran; at 20 ℃; for 2h;
 

1219089-85-6 Upstream products

  • 1219089-84-5
    1219089-84-5

    2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-N6-isobutyryl-riboadenosine

  • 40615-36-9
    40615-36-9

    4,4'-dimethoxytrityl chloride

1219089-85-6 Downstream products

  • 1219089-86-7
    1219089-86-7

    2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-5'-O-(4,4'-dimethoxytrityl)-N6-isobutyryl-adenosine-3'-O-(β-cyanoethyl)-N,N-diisopropyl-phosphoramidite

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