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102691-36-1

Q: What is the 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite?

2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite is Clear to cloudy colourless liquid, while it's Molecular Formula is C15H32N3OP. Clear to cloudy colourless liquid 2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphordiamidite was used:in preparation of prosphoramidite reagent, required for synthesis of 12-mer oligodeoxynucleotideas phosphorylating agent in synthesis of 1,2-diacyl-sn-glycerophosphatidylserinein situ preparation of deoxyribonucleoside phosphoramiditesin preparation of 2′-deoxy-2′-fluoro-3′-O-(β-cyanoethyl-N,N-diisopropylphosphoramidic)-5′-O-(4-methoxytrityl)-4′-thio-β-D-arabinouridine and 1-(3-O-(β-cyanoethyl-N,N-diisopropylphosphoramidic)-2-deoxy-2-fluoro-5-O-(4,4′-dimethoxytrityl)-4-thio-β-D-arabinofuranosyl)-thymineas reagent for synthesizing phosphitylated nucleotides

Q: What is the CAS number for 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite?

The CAS number of 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite is 102691-36-1.

Product Name：2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite
Molecular Formula：C₁₅H₃₂N₃OP
Purity：99%
Molecular Weight：301.412

Inquiry

Product Details;

CasNo： 102691-36-1

Molecular Formula： C₁₅H₃₂N₃OP

Appearance： Clear to cloudy colourless liquid

Hot Sale Top Purity Best Price 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 102691-36-1

Molecular Formula:C15H32N3OP
Molecular Weight:301.412
Appearance/Colour:Clear to cloudy colourless liquid
Refractive Index:n20/D 1.470(lit.)
Boiling Point:298.1 °C at 760 mmHg
PKA:6.78±0.70(Predicted)
Flash Point:177.9 °C
PSA：53.09000
Density:0.949 g/mL at 25 °C(lit.)
LogP:4.38118

102691-36-1 Relevant articles

83. Nucleotide Coupling in Reverse Micelles

Boehler, Christof,Bannwarth, Willi,Luisi, Pier Luigi,Giustini, Mauro

, p. 1341 - 1351 (1993)

Nucleotide coupling was investigated in ...

Voriconazole phosphorylcholine ester inner salt key intermediate and preparation method thereof

-

Paragraph 0048-0052, (2021/06/22)

The invention relates to the field of ph...

Voriconazole phosphorylcholine ester inner salt intermediates, preparation method and method for preparing voriconazole phosphorylcholine ester inner salt

-

Paragraph 0075-0079, (2021/06/23)

The invention relates to the field of ph...

An effective reagent to functionalize alcohols with phosphocholine

Xu, Lianyan L.,Berg, Lawrence J.,Jamin Keith,Townsend, Steven D.

supporting information, p. 767 - 770 (2020/02/11)

Phosphocholine is a small haptenic molec...

Total Synthesis of the Congested, Bisphosphorylated Morganella morganii Zwitterionic Trisaccharide Repeating Unit

Keith, D. Jamin,Townsend, Steven D.

supporting information, p. 12939 - 12945 (2019/08/22)

Zwitterionic polysaccharides (ZPSs) acti...

102691-36-1 Process route

: 76101-30-9
2-cyanoethyl phosphorodichloridite

: 108-18-9
diisopropylamine

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

Conditions

Conditions	Yield
In tetrahydrofuran; at -10 - 20 ℃; for 73.5h;	88.5%
In diethyl ether; at 20 ℃; for 12h;	79%
In diethyl ether; 1 h, -10 degC, r.t., overnight;	64%
diisopropylamine; With trichlorophosphate; In hexane; at 0 ℃; for 0.333333h; 2-cyanoethyl phosphorodichloridite; In hexane; at 0 - 20 ℃; for 6h;
diisopropylamine; With potassium carbonate; In hexane; at -15 ℃; for 0.333333h; 2-cyanoethyl phosphorodichloridite; In hexane; at -5 - 20 ℃;
diisopropylamine; With potassium carbonate; In hexanes; at -15 ℃; for 0.333333h; 2-cyanoethyl phosphorodichloridite; at -5 - 20 ℃;
diisopropylamine; With trichlorophosphate; In hexanes; at 0 ℃; for 0.333333h; 2-cyanoethyl phosphorodichloridite; In hexanes; at 0 - 20 ℃; for 6h;
In acetonitrile; at 0 - 25 ℃; for 12h;
In acetonitrile; at 0 - 23 ℃; for 12h; Inert atmosphere;	72 %Spectr.
2-cyanoethyl phosphorodichloridite; diisopropylamine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere; With triethylamine; In dichloromethane; at -5 - 0 ℃; for 6h; Inert atmosphere;
2-cyanoethyl phosphorodichloridite; diisopropylamine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere; With triethylamine; In dichloromethane; at -5 - 0 ℃; for 6h; Inert atmosphere;

: 108-18-9
diisopropylamine

: 109-78-4
3-Hydroxypropionitrile

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

Conditions

Conditions	Yield
diisopropylamine; With phosphorus trichloride; In acetonitrile; for 1h; Inert atmosphere; 3-Hydroxypropionitrile; In hexane; acetonitrile; for 1.5h; Inert atmosphere;	42%
3-Hydroxypropionitrile; With N-ethyl-N,N-diisopropylamine; 1-butyl-methylpyrrolidinium bis(trifluoromethylsulfonyl)amide; phosphorus trichloride; for 0.5h; Inert atmosphere; diisopropylamine; for 2h; chemoselective reaction; Inert atmosphere;	31%
With phosphorus trichloride; Yield given. Multistep reaction; 1.) Et₂O, -78 deg C, 1 h, 24 deg C, 1 h, 2.) -20 deg C, 10 min, 24 deg C, 1.5 h;
With phosphorus trichloride; In acetonitrile;
diisopropylamine; With phosphorus trichloride; In acetonitrile; at 20 ℃; for 1h; 3-Hydroxypropionitrile; In hexane; acetonitrile; at 20 ℃; for 1.5h;
diisopropylamine; With phosphorus trichloride; In acetonitrile; at 20 ℃; 3-Hydroxypropionitrile; In n-heptane; acetonitrile; at 20 ℃; for 1.5h;
diisopropylamine; With phosphorus trichloride; In acetonitrile; 3-Hydroxypropionitrile; In n-heptane; acetonitrile;

102691-36-1 Upstream products

25152-20-9
5'-amino-5'-deoxythymidine
76101-30-9
2-cyanoethyl phosphorodichloridite
108-18-9
diisopropylamine
109-78-4
3-Hydroxypropionitrile

102691-36-1 Downstream products

330628-04-1
5'-O-(4,4'-dimethoxytrityl)-N-dimethyl-formamidine-2'-deoxyguanosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite
133339-60-3
2-<(N-benzyloxycarbonyl)amino>ethyl 2-cyanoethyl H-phosphonate
139472-73-4
Benzoic acid 1-{2-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-1-octadecanoylamino-ethyl}-hexadecyl ester
154656-78-7
N⁶-dimethylformamidine-2'-deoxyadenosine-3'-diisopropylaminocyanoethyl phosphoramidite

Product Classification

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102691-36-1

Product Details;

Hot Sale Top Purity Best Price 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 102691-36-1

102691-36-1 Relevant articles

83. Nucleotide Coupling in Reverse Micelles

Boehler, Christof,Bannwarth, Willi,Luisi, Pier Luigi,Giustini, Mauro

, p. 1341 - 1351 (1993)

Voriconazole phosphorylcholine ester inner salt key intermediate and preparation method thereof

-

Paragraph 0048-0052, (2021/06/22)

Voriconazole phosphorylcholine ester inner salt intermediates, preparation method and method for preparing voriconazole phosphorylcholine ester inner salt

-

Paragraph 0075-0079, (2021/06/23)

An effective reagent to functionalize alcohols with phosphocholine

Xu, Lianyan L.,Berg, Lawrence J.,Jamin Keith,Townsend, Steven D.

supporting information, p. 767 - 770 (2020/02/11)

Total Synthesis of the Congested, Bisphosphorylated Morganella morganii Zwitterionic Trisaccharide Repeating Unit

Keith, D. Jamin,Townsend, Steven D.

supporting information, p. 12939 - 12945 (2019/08/22)

102691-36-1 Process route

102691-36-1 Upstream products

102691-36-1 Downstream products

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